|
"Association of NOD2 leucine-rich
variants with susceptibility to Crohn's disease,"
by Jean-Pierre Hugot
and 19 others, Nature, 411(6837):599-603, 31 May 2001.
[Authors' affiliations: 14 European
institutions]
Abstract: "Crohn's disease and
ulcerative colitis, the two main types of chronic inflammatory bowel disease,
are multifactorial conditions of unknown aetiology. A susceptibility locus for
Crohn's disease has been mapped to chromosome 16. Here we have used a
positional-cloning strategy, based on linkage analysis followed by linkage
disequilibrium mapping, to identify three independent associations for Crohn's
disease: a frameshift variant and two missense variants of NOD2,
encoding a member of the Apaf-1/Ced-4 superfamily of apoptosis regulators that
is expressed in monocytes. These NOD2 variants alter the structure of
either the leucine-rich repeat domain of the protein or the adjacent region.
NOD-2 activates nuclear factor NF-kappaB; this activating function is
regulated by the carboxy-terminal leucine-rich repeat domain, which has an
inhibitory role and also acts as an intracellular receptor for components of
microbial pathogens. These observations suggest that the NOD2 gene
product confers susceptibility to Crohn's disease by altering the recognition
of these components and/or by over-activating NF-kappaB in monocytes, thus
documenting a molecular model for the pathogenic mechanism of Crohn's disease
that can now be further investigated."
This 2001 report from Nature was cited
44 times in current journal articles indexed in the ISI database
during July-August 2002. No other non-review paper published within the last
two years and indexed in the Hot Papers category of Clinical Medicine received
as many citations during that two-month period. Prior to the most recent
bimonthly count, citations to the paper have accrued as follows:
May-June 2002: 33 citations
March-April 2002: 25
January-February 2002: 22
November-December 2001: 18
September-October 2001: 12
July-August 2001: 8
May-June 2001: 2
Total citations to date: 164
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
updated CD containing the most recent bimonthly data is mailed with every new
issue of Science
Watch,
six times a year. The CD also includes an electronic version of the Science
Watch
issue in HTML format, for personal desktop access.)
Previous Page | Return to SCI-BYTES
Main Menu
| Return to 2002 Menu
If you came from the Thomson Scientific Web site, click
here to return
|
cites
:
