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"Crystal structure of
rhodopsin: a G protein coupled receptor,"
by Krzysztof Palczewski and 11 others, Science,
289(5840):739-45, 4 August 2000.
[Authors' affiliations:
University of Washington, Seattle; RIKEN Harima Institute, Hyogo,
Japan; Tokyo Institute of Technology, Yokohama, Japan]
Abstract: "Heterotrimeric
guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs)
respond to a variety of different external stimuli and activate G
proteins. GPCRs share many structural features, including a bundle
of seven transmembrane alpha helices connected by six loops of
varying lengths. We determined the structure of rhodopsin from
diffraction data extending to 2.8 angstroms resolution. The highly
organized structure in the extracellular region, including a
conserved disulfide bridge, forms a basis for the arrangement of
the seven-helix transmembrane motif. The ground-state chromophore,
11-cis-retinal, holds the transmembrane region of the protein in
the inactive conformation. Interactions of the chromophore with a
cluster of key residues determine the wavelength of the maximum
absorption. Changes in these interactions among rhodopsins
facilitate color discrimination. Identification of a set of
residues that mediate interactions between the transmembrane
helices and the cytoplasmic surface, where G-protein activation
occurs, also suggests a possible structural change upon
photoactivation."
This 2000 report from Science
was cited 61 times in current journal articles
indexed in the ISI database during May-June 2002. Repeating its
performance from the previous, March-April count, this is
currently the third-most-cited paper in biology published in the
last two years, excluding reviews. Prior to the most recent
bimonthly count, citations to the paper have accrued as follows:
March-April 2002: 52
citations
January-February 2002: 30
November-December 2001: 49
September-October 2001: 44
July-August 2001: 49
May-June 2001: 34
March-April 2001: 32
January-February 2001: 23
November-December 2000: 9
September-October 2000: 4
July-August 2000: 1
Total citations to date: 388
SOURCE: Hot
Papers Database (Included with a subscription to the ISI print
newsletter Science
Watch®, available from the ISI
Research Services Group. Packaged on a CD-ROM that is mailed
with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited
papers published during the last two years. User interface permits
searching by author, organization, journal, field, and more. Total
citations, as well as citations accrued during successive
bimonthly periods, can be assessed and graphed. An updated CD
containing the most recent bimonthly data is mailed with every new
issue of Science
Watch, six times a year. The CD also includes
an electronic version of the Science
Watch issue in HTML format, for personal
desktop access.)
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