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"Proteome survey reveals modularity of the
yeast cell machinery," by Anne-Claude Gavin and 32 others, Nature,
440(7084): 631-6, 30 March 2006.
[Authors' affiliations: Cellzome AG,
Heidelberg, Germany; EMBL, Heidelberg, Germany; MPI-MG, MPI-IB, Berlin,
Germany; Austrian Academy of Sciences, Vienna]
Abstract: "Protein complexes are key
molecular entities that integrate multiple gene products to perform cellular
functions. Here we report the first genome-wide screen for complexes in an
organism, budding yeast, using affinity purification and mass spectrometry.
Through systematic tagging of open reading frames (ORFs), the majority of
complexes were purified several times, suggesting screen saturation. The
richness of the data set enabled a de novo characterization of the
composition and organization of the cellular machinery. The ensemble of
cellular proteins partitions into 491 complexes, of which 257 are novel,
that differentially combine with additional attachment proteins or protein
modules to enable a diversification of potential functions. Support for this
modular organization of the proteome comes from integration with available
data on expression, localization, function, evolutionary conservation,
protein structure and binary interactions. This study provides the largest
collection of physically determined eukaryotic cellular machines so far and
a platform for biological data integration and modelling."
This 2006 report in Nature was cited
30 times in current journal articles indexed by Thomson Scientific during
July-August 2007. Only two other biology reports, aside from reviews,
received higher numbers of citations during that two-month period. Prior to
the most recent bimonthly count, citations to the paper have accrued as
follows:
May-June 2007: 28 citations
March-April 2007: 14
January-February 2007: 23
November-December 2006: 18
September-October 2006: 11
July-August 2006: 12
May-June 2006: 2
Total citations to date: 138
SOURCE: Hot
Papers Database (Included with a subscription to the print newsletter Science
Watch®, available from the
Research Services Group. Packaged on a CD that is mailed with each Science
Watch issue, the Hot
Papers Database contains data on hundreds of highly cited papers published
during the last two years. User interface permits searching by author,
organization, journal, field, and more. Total citations, as well as citations
accrued during successive bimonthly periods, can be assessed and graphed. An
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