ccording
to a recent analysis of the ISI
Essential
Science Indicators
Web product, the work of Dr. Monique Lacroix garnered the
highest percent increase in terms of total citations in the
field of Agricultural Sciences. Her current citation record
in this field includes 40 papers cited a total of 394 times.
Dr. Lacroix is Associate Professor at INRS-Institut Armand-Frappier
and a researcher at the Canadian Irradiation Center (CIC),
which is a joint venture between INRS-Institut Armand-Frappier
and MDS Nordion Inc. In the interview below, she talks with
in-cites about her highly cited work.
|
Why do you think your work is
highly cited?
|

“Since food contamination is still an enormous public health problem, we think that irradiation technology would be able to assure the innocuity of foods, to prolong the shelf life, and to reduce the food poisoning level in the world.”
|
|
The development of biodegradable films is an important issue for
environmental protection. Natural polymers offer great
opportunities. For example, food by-products like whey or chitosan
can be used for the development of biodegradable and active films or
coating. Moreover, the emergence of natural antioxidants and
antimicrobial compounds or the importance of probiotics during the
last decade allowed us to adapt and develop different technologies
in order to encapsulate and preserve their stability and/or their
viability. Our encapsulation / immobilization methods provide numerous
promising applications for the development of bioactive food
packaging, nutraceutical foods and pharmaceutical products, with
regard to consumer health and safety. Research activities on the
selection of natural antimicrobial (bacteriocins, spice and plant
extracts) and antioxidant compounds (polyphenols, medicinal plants,
and spice extracts) also include the controlled release of active
molecules, the control of contamination with pathogens, and the
development of nutraceutical foods. The use of these natural
compounds can also increase the radiation sensitivity of bacteria
and protect at the same time the sensorial quality of foods. Since
food contamination is still an enormous public health problem, we
think that irradiation technology would be able to assure the
innocuity of foods, to prolong the shelf life, and to reduce the
food poisoning level in the world. We have also purified two novel
bacteriocin-producing strains of Lactococcus lactis and Pediococcus
acidilactici isolated from adult human feces. The consumption of
food products containing these bacteriocin-producing human
microorganisms can help to fight against pathogens, especially those
presenting resistance to antibiotics. It is a very promising
technology in the way of health and prevention of infection and
could be useful to protect cultures in fermented foods or used
during food processing. We’ve been working for 20 years on
nutraceutical foods and food preservation using new technical
insights such as natural antimicrobial compounds, gamma irradiation,
modified atmospheres, and biodegradable and edible packaging and
coatings via modification of biopolymers.
What are the circumstances which led you to your work?
Since the beginning of my career, I have been a professor in the
Research Laboratories in Sciences Applied to Food and a researcher
at the Canadian Irradiation Center, a unique center for excellence
in the world to collaborate with the food industry in developing new
technologies, ensuring safe production methods, improving food
preservation time, and in improving new high-quality products. I am
also working on combined irradiation treatments to improve food
safety, while protecting nutritional value and reducing nutritional
loss. I was involved in the development of four new technologies: 1)
a new patented method of inducing "cross-linking" of milk
proteins through gamma radiation, which produces a sterile,
biodegradable, water-resistant packaging material, with excellent
mechanical properties; 2) an edible food coating used commercially
to prolong the shelf life and restrict the passage of water between
the constituents of prepared food; 3) a new patented irradiation
process, which combines active natural compounds (spice extracts)
with irradiation treatment, aimed at reducing the irradiation doses
required to eliminate bacterial contamination in ground meat and
chicken and protecting the sensorial quality of the product; and 4)
a new patented cross-link method for edible coatings, granules, or
packaging films used for encapsulation of probiotic bacteria,
polyphenolic compounds, vitamins, and minerals. This cross-link
method allows a controlled release of the active compounds to the
foodstuff ensuring a longer period of efficacy, the protection of
the bioactivities of compounds (e.g., antioxidant properties) and
the protection of the viability of probiotic bacteria. Finally I am
also involved in the development of nutraceutical products,
including the evaluation of the antioxidant and antimicrobial
properties of secondary metabolites of plants such as the
polyphenols of berries or by-products of maple syrup, and the
evaluation of the efficacy of probiotic bacteria to eliminate
pathogenic bacteria and stimulate the immune system. Two novel
bacteriocin-producing bacterial strains have been recently isolated
with promising important commercial application.
Would you describe the significance of this work for your
field?
Worldwide alimentary self-sufficiency and security are the main
objectives to reach in order to protect human health, reduce
alimentary losses/waste, and suppress hunger and malnutrition. In
spite of the development of food technologies to avoid
contamination, the food loss is still high. Moreover, society has to
cope with diseases resulting from the development of pathogenic
microorganisms, parasites, and viruses that may be found naturally
in foods and also by the production of toxic substances, such as
verotoxin-producing bacteria and aflatoxin produced by moulds.
Microbial contamination is responsible for a variety of alimentary
diseases such as toxoplasmosis, salmonellosis, campylobacteriosis,
listeriosis, trichinellosis, cholera, and many more. Food-borne
infections are estimated to affect 25% of the American population
each year. According to the United Nations, more than 30% of the
mortality rate worldwide is caused by alimentary diseases. New
methods such as food irradiation treatment, natural antimicrobial
compounds, and the addition of probiotics and their bacteriocins to
foods are needed to prevent the associated diseases. Due to an
outbreak of antibiotic-resistant bacteria, it becomes urgent to
develop natural antibiotics with a specific antimicrobial spectrum.
A major healthcare trend in the last decade has also been the
increased use of complementary and alternative medicine and
nutritional supplements such as lactic acid bacteria and natural
antioxidants (free radical scavengers). Oxidative stress by free
radicals is an important event in the cell that can cause aging and
human degenerative diseases including, cancer, heart diseases,
multiple sclerosis, Parkinson’s disease, autoimmune disease, and
senile dementia. Polyphenols from plants, fruits, and vegetables
having high antioxidant activities are attractive to the food
industry, prompting their use as replacements for synthetic
antioxidants and also as nutraceuticals, playing a role in
preventing many diseases. We work precisely with these compounds and
we’re able to protect them with our polymeric matrixes, in order
to optimize their functionality and obtain a high level of activity.
Where do you see this research going 10 years from now?
For the next 10 years, our work will be developed and applied as
major driving forces using bioactive compounds alone or in
combination with emerging technologies like irradiation and
compatible biopolymers to respond in a healthy way to the increasing
consumer demand for: minimally processed foods, changes in retail
and distribution associated with worldwide markets, new products
logistics, new distribution trends (via the Internet), automatic
handling systems (in grocery stores), and stricter governmental
requirements to reduce food-borne disease and to assure world-wide
alimentary self-sufficiency and security. Consequently, a new
approach in food packaging regulations will be more and more needed
in the future. Although rather limited because of the legal status
on additives, the current applications of bioactive food packaging
are promising, with major potential applications for meat, fish,
poultry, bakery goods, cheese, fruits, and vegetables.
What lessons would you draw from your work to share with the
next generation of researchers?
Realize your dreams and always focus on them. Always read the
literature with a critical eye: an experimental work could be
designed in different ways that have an influence on the
interpretation of results. Never be influenced by outside
controversy or opinion. Never be discouraged by a challenge or
unexpected results; be a hard worker. Realize also that it is not
necessary to work in a well-recognized institute in your field or to
use the most sophisticated new technologies or equipment to have an
impact in science.
Monique Lacroix, Ph.D.
Institut Armand-Frappier
Institut national de la recherche scientifique
Quebec, Canada
| Dr. Monique Lacroix's
most-cited paper with 105 cites to date: |
|
Fillion, J., et al.,
"Multiresidue determination of pesticides in fruit and vegetables by gas chromatography mass-selective detection and liquid chromatography with fluorescence detection,"
(J AOAC Int 78(5): 1252-66, Sep-Oct 1995). |
|
Source:
ISI
Essential Science Indicators |
|
|